::XIST (gene)


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{{#invoke:Infobox3cols|infobox}}{{safesubst:#invoke:Check for unknown parameters|check|unknown=|ignoreblank=y|checkpositional=y | child| subbox| bodyclass| bodystyle| title| titleclass| titlestyle| above| abovestyle| aboveclass| aboverowclass| subheader| subheaderstyle| subheaderclass| subheaderrowclass1| subheader2| subheaderrowclass2| image| imageclass| imagestyle| caption| captionstyle| image1| caption1| imagerowclass1| image2| caption2| imagerowclass2| headerstyle| labelstyle| multidatastyle| datastyle| datastylea| datastyleb| datastylec| regexp1 = header[%d][%d]*| regexp2 = label[%d][%d]*| regexp3 = data[%d][%d]*[abc]?| regexp4 = class[%d][%d]*[abc]?| regexp5 = rowclass[%d][%d]*| regexp6 = rowstyle[%d][%d]*| regexp7 = rowcellstyle[%d][%d]*| below| belowstyle| belowclass| belowrowclass| name }} Xist (X-inactive specific transcript) is an RNA gene on the X chromosome of the placental mammals that acts as a major effector of the X inactivation process.<ref name="entrez_7503">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> It is a component of the Xic - X-chromosome inactivation centre<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> - along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2).<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The Xist RNA, a large (17 kb in humans)<ref name="pmid1423611">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> transcript, is expressed on the inactive chromosome and not on the active one. It is processed in a similar way to mRNAs, through splicing and polyadenylation. However, it remains untranslated. It has been suggested that this RNA gene evolved at least partly from a protein coding gene that became a pseudogene.<ref name="Dur09">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The inactive X chromosome is coated with this transcript, which is essential for the inactivation.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> X chromosomes lacking Xist will not be inactivated, while duplication of the Xist gene on another chromosome causes inactivation of that chromosome.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

XIST (gene) sections
Intro   Function    Gene location    Transcript organization    Xist Inactivation Center (XIC)    Regulation of the Xist promoter    Dosage compensation    X inactivation cycle    Disease linkage    Interactions    See also    References    Further reading    External links   

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