- Horace-Bénédict de Saussure (1740–1799), Swiss physicist and Alpine traveller
- Henri Louis Frédéric de Saussure (1829–1905), Swiss mineralogist and entomologist (taxonomist), and father of Ferdinand, Léopold and René.
- Hermine de Saussure (1901–1984), female sailing pioneer and scholar, specialist of Jean-Jacques Rousseau daughter of Léopold and mother of Delphine Seyrig
- Éric de Saussure (1925–2007), Swiss artist and member of the Taizé Community
- Henry William de Saussure (1763–1839) American lawyer, State legislator from South Carolina, President of the U.S. Mint
- William F. De Saussure (1792–1870), U.S. Senator from South Carolina
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