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::Restless legs syndrome

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Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED)<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> or Wittmaack-Ekbom syndrome, is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> It most commonly affects the legs, but can affect the arms, torso, head, and even phantom limbs.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Moving the affected body part modulates the sensations, providing temporary relief.

RLS sensations range from pain or an aching in the muscles, to "an itch you can't scratch," a "buzzing sensation," an unpleasant "tickle that won't stop," or even a "crawling" feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.<ref name=pmid14592341>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Additionally, most individuals with RLS have periodic limb movement disorder (limbs jerking during sleep), which is an objective physiologic marker of the disorder and is associated with sleep disruption.<ref name="pmid17634447"/> It can be caused by low iron levels.<ref name=AFP2013/>

Treatment is often with levodopa or a dopamine agonist such as pramipexole.<ref name=AFP2013/> Some controversy surrounds the marketing of drug treatments for RLS. It is a "spectrum" disease with some people experiencing only a minor annoyance and others having major disruption of sleep and impairments in quality of life.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


Restless legs syndrome sections
Intro   Signs and symptoms   Causes  Mechanism  Diagnosis   Prevention   Treatment  Prognosis  Epidemiology  History  Controversy  See also  References  External links  

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