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::Progestogen

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Steroidogenesis, with progestogens and their precursors inside the yellow box.

Progestogens (also sometimes spelled progestagens or gestagens)<ref name="KingBrucker2010">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref> are a class of steroid hormones that bind to and activate the progesterone receptor (PR).<ref name="ClarkHarvey2011">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref><ref name="Bhattacharya2003">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref> The most important progestogen in the body is progesterone (P4). Other endogenous progestogens include 17α-hydroxyprogesterone, 20α-dihydroprogesterone, 5α-dihydroprogesterone, 11-deoxycorticosterone, and 5α-dihydrodeoxycorticosterone. Synthetic progestogens are generally referred to as progestins.<ref name="ClarkHarvey2011" /> However, the terms progesterone, progestogen, and progestin are frequently used interchangeably both in the scientific literature and in clinical settings.<ref name="KingBrucker2010" /><ref name="Parker-Pope2008">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref>

The progestogens are one of the five major classes of steroid hormones, in addition to the androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as the neurosteroids. All progestogens are characterized by their basic 21-carbon skeleton, called a pregnane skeleton (C21). In similar manner, the estrogens possess an estrane skeleton (C18), and androgens, an andrane skeleton (C19).

The progestogens are named for their function in maintaining pregnancy (i.e., progestational), although they are also present at other phases of the estrous and menstrual cycles.<ref name="ClarkHarvey2011" /><ref name="Bhattacharya2003" />


Progestogen sections
Intro  Functions  Uses  References  Further reading  [[Progestogen?section=External</a>_links|External</a> links]]  

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