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Classification by structure::Progestin

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Classification by structure Progestins used clinically (and/or in veterinary medicine) can be broadly categorized by chemical structure as follows:<ref name="pmid19434889">{{#invoke:ParseVauthors|parse}}</ref><ref name="ArtiniGenazzani2001">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref>

Comparison

The different structural classes of progestins have different pharmacological profiles. 19-Norprogesterone and retroprogesterone derivatives tend to be pure progestogens. 17α-Hydroxyprogesterone derivatives tend to have antiandrogen and glucocorticoid properties. A notable exception is hydroxyprogesterone caproate, which is a pure progestogen. Another notable exception is medroxyprogesterone acetate, which has weak androgenic actions. 17α-Ethynyltestosterone and 19-nortestosterone derivatives often possess weak androgenic actions.<ref name="BoxtelSantoso2008">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref><ref name="GomelBrill2010">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref> Gestodene is a 19-nortestosterone derivative with antimineralocorticoid properties. Spirolactones tend to have antimineralocorticoid and antiandrogen actions. Progesterone itself has antimineralocorticoid properties and very weak glucocorticoid actions.


Progestin sections
Intro  History  Examples  Classification by structure  Methods of progestin-based contraception  See also  References  

Classification by structure
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