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Progestins are synthetic<ref name=merriam-webster>Merriam-Webster's medical Dictionary > progestin Retrieved on Feb 13, 2010</ref> progestogens that have progestogenic effects similar to those of progesterone.<ref>MedicineNet > progestin definition Last Editorial Review: 6/14/2012</ref> The two most common uses of progestins are for hormonal contraception (either alone or with an estrogen), and to prevent endometrial hyperplasia from unopposed estrogen in hormone replacement therapy. Progestins are also used to treat secondary amenorrhea, dysfunctional uterine bleeding and endometriosis, and as palliative treatment of endometrial cancer, renal cell carcinoma, breast cancer, and prostate cancer. High-dose megestrol acetate is used to treat anorexia, cachexia, and AIDS-related wasting.

Progesterone (or sometimes dydrogesterone or hydroxyprogesterone caproate) is used for luteal support in IVF protocols, questionably for treatment of recurrent pregnancy loss, and for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth.<ref name="Loose 2006">{{#invoke:citation/CS1|citation |CitationClass=book }}</ref>

Progestins are also used in judicial chemical castration of sex offenders and in the treatment of individuals suffering from unwanted sexual urges (e.g., from hypersexuality, paraphilias, etc.).


Progestin sections
Intro  History  Examples  Classification by structure  Methods of progestin-based contraception  See also  References  

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