::Photoreceptor cell


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A photoreceptor cell is a specialized type of neuron found in the retina that is capable of phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation) into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential.

There are currently three known types of photoreceptor cells in mammalian eyes: rods, cones, and photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each contributing information used by the visual system to form a representation of the visual world, sight. The rods are narrower than the cones and distributed differently across the retina, but the chemical process in each that supports phototransduction is similar.<ref>"eye, human." Encyclopædia Britannica. Encyclopaedia Britannica Ultimate Reference Suite. Chicago: Encyclopædia Britannica, 2010.</ref> A third class of photoreceptor cells was discovered during the 1990s:<ref name=Foster>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> the photosensitive ganglion cells. These cells do not contribute to sight directly, but are thought to support circadian rhythms and pupillary reflex.

There are major functional differences between the rods and cones. Rods are extremely sensitive, and can be triggered by a single photon.<ref name=Hecht>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref><ref name=Baylor>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> At very low light levels, visual experience is based solely on the rod signal. This explains why colors cannot be seen at low light levels: only one type of photoreceptor cell is active.

Cones require significantly brighter light (i.e., a larger numbers of photons) in order to produce a signal. In humans, there are three different types of cone cell, distinguished by their pattern of response to different wavelengths of light. Color experience is calculated from these three distinct signals, perhaps via an opponent process.<ref name=Hurvich>{{#invoke:citation/CS1|citation |CitationClass=book }}</ref> The three types of cone cell respond (roughly) to light of short, medium, and long wavelengths. Note that, due to the principle of univariance, the firing of the cell depends upon only the number of photons absorbed. The different responses of the three types of cone cells are determined by the likelihoods that their respective photoreceptor proteins will absorb photons of different wavelengths. So, for example, an L cone cell contains a photoreceptor protein that more readily absorbs long wavelengths of light (i.e., more "red"). Light of a shorter wavelength can also produce the same response, but it must be much brighter to do so.

The human retina contains about 120 million rod cells and 6 million cone cells. The number and ratio of rods to cones varies among species, dependent on whether an animal is primarily diurnal or nocturnal. Certain owls, such as the tawny owl,<ref>"Owl Eyesight" at</ref> have a tremendous number of rods in their retinae. In addition, there are about 2.4 million to 3 million ganglion cells in the human visual system, the axons of these cells form the 2 optic nerves, 1 to 2% of them photosensitive.

The pineal and parapineal glands are photoreceptive in non-mammalian vertebrates, but not in mammals. Birds have photoactive cerebrospinal fluid (CSF)-contacting neurons within the paraventricular organ that respond to light in the absence of input from the eyes or neurotransmitters. Invertebrate photoreceptors in organisms such as insects and molluscs are different in both their morphological organization and their underlying biochemical pathways. Described here are human photoreceptors.

Photoreceptor cell sections
Intro   Histology    Humans    Phototransduction    Function    Development    Signaling    Ganglion cell (non-rod non-cone) photoreceptors    See also    References    Bibliography    External links   

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