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{{#invoke:Infobox3cols|infobox}}{{safesubst:#invoke:Check for unknown parameters|check|unknown=|ignoreblank=y|checkpositional=y | child| subbox| bodyclass| bodystyle| title| titleclass| titlestyle| above| abovestyle| aboveclass| aboverowclass| subheader| subheaderstyle| subheaderclass| subheaderrowclass1| subheader2| subheaderrowclass2| image| imageclass| imagestyle| caption| captionstyle| image1| caption1| imagerowclass1| image2| caption2| imagerowclass2| headerstyle| labelstyle| multidatastyle| datastyle| datastylea| datastyleb| datastylec| regexp1 = header[%d][%d]*| regexp2 = label[%d][%d]*| regexp3 = data[%d][%d]*[abc]?| regexp4 = class[%d][%d]*[abc]?| regexp5 = rowclass[%d][%d]*| regexp6 = rowstyle[%d][%d]*| regexp7 = rowcellstyle[%d][%d]*| below| belowstyle| belowclass| belowrowclass| name }} PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.<ref name = "entrez"/><ref name="pmid1419001">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref><ref name="pmid9286702">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.<ref name = "entrez">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,<ref name="pmid8778289">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.<ref name="pmid11283303">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.<ref name="stabilization_plasticity">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


DLG4 sections
Intro  MAGUK superfamily and constituent domains  Model organisms  Interactions  See also  References  External links  

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{{#invoke:Infobox3cols|infobox}}{{safesubst:#invoke:Check for unknown parameters|check|unknown=|ignoreblank=y|checkpositional=y | child| subbox| bodyclass| bodystyle| title| titleclass| titlestyle| above| abovestyle| aboveclass| aboverowclass| subheader| subheaderstyle| subheaderclass| subheaderrowclass1| subheader2| subheaderrowclass2| image| imageclass| imagestyle| caption| captionstyle| image1| caption1| imagerowclass1| image2| caption2| imagerowclass2| headerstyle| labelstyle| multidatastyle| datastyle| datastylea| datastyleb| datastylec| regexp1 = header[%d][%d]*| regexp2 = label[%d][%d]*| regexp3 = data[%d][%d]*[abc]?| regexp4 = class[%d][%d]*[abc]?| regexp5 = rowclass[%d][%d]*| regexp6 = rowstyle[%d][%d]*| regexp7 = rowcellstyle[%d][%d]*| below| belowstyle| belowclass| belowrowclass| name }} PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.<ref name = "entrez"/><ref name="pmid1419001">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref><ref name="pmid9286702">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.<ref name = "entrez">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,<ref name="pmid8778289">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.<ref name="pmid11283303">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.<ref name="stabilization_plasticity">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


DLG4 sections
Intro  MAGUK superfamily and constituent domains  Model organisms  Interactions  See also  References  External links  

PREVIOUS: IntroNEXT: MAGUK superfamily and constituent domains
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