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::Catechol-O-methyl transferase

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Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene.<ref name="pmid1572656">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.<ref name="pmid11873938">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> COMT was first discovered by the biochemist Julius Axelrod in 1957.<ref name="pmid13467217">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


Catechol-O-methyl transferase sections
Intro   Function    Genetics in humans    Nomenclature    COMT inhibitors    See also   Additional images   References    Further reading    External links   

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CitationClass=book }}</ref>

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene.<ref name="pmid1572656">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.<ref name="pmid11873938">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> COMT was first discovered by the biochemist Julius Axelrod in 1957.<ref name="pmid13467217">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


Catechol-O-methyl transferase sections
Intro   Function    Genetics in humans    Nomenclature    COMT inhibitors    See also   Additional images   References    Further reading    External links   

PREVIOUS: IntroNEXT: Function
<<>>