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19-Norandrostenedione (4-estrene-3,17-dione, NOR) is a precursor of the anabolic steroid nandrolone. Until 2005 19-Norandrostenedione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> 19-Norandrostenedione is readily metabolized to nandrolone after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).<ref name=sarm>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

Scientific studies have shown that oral administration of 19-norandrostenedione is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

In vivo experiments in castrated rats demonstrated that subcutaneous treatment with 19-norandrostenedione resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolone, 19-norandrostenedione highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.<ref name=sarm/>

In the early 2000s, contamination of androstenedione products with traces of 19-norandrostenedione caused false positives for doping tests for nandrolone because 19-norandrosterone is a metabolite of both nandrolone and 19-norandrostenedione. In a randomized controlled trial trace contamination of androstenedione with 19-norandrostenedione was sufficient for users of androstendione to test positive for nandrolone.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> This detail became less relevant after 19-norandrostenedione and androstenedione were banned by major sporting bodies.


19-Norandrostenedione sections
Intro   See also    References   

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Journal::first    After::schedule    World::correct    Title::legal    Androgen::receptor    Volume::anabolic

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19-Norandrostenedione (4-estrene-3,17-dione, NOR) is a precursor of the anabolic steroid nandrolone. Until 2005 19-Norandrostenedione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> 19-Norandrostenedione is readily metabolized to nandrolone after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).<ref name=sarm>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

Scientific studies have shown that oral administration of 19-norandrostenedione is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

In vivo experiments in castrated rats demonstrated that subcutaneous treatment with 19-norandrostenedione resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolone, 19-norandrostenedione highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.<ref name=sarm/>

In the early 2000s, contamination of androstenedione products with traces of 19-norandrostenedione caused false positives for doping tests for nandrolone because 19-norandrosterone is a metabolite of both nandrolone and 19-norandrostenedione. In a randomized controlled trial trace contamination of androstenedione with 19-norandrostenedione was sufficient for users of androstendione to test positive for nandrolone.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> This detail became less relevant after 19-norandrostenedione and androstenedione were banned by major sporting bodies.


19-Norandrostenedione sections
Intro   See also    References   

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