Actions

(6S)-6-Fluoroshikimic acid

::concepts



(6S)-6-Fluoroshikimic acid
colspan=2 style="background:#f8eaba; text-align:center;" Names
colspan=2 style="background:#f8eaba; text-align:center;" Identifiers{{#invoke:TemplatePar check template=Template:Chembox Identifiers opt=

3DMet= ATCCode= ATCCode_prefix= ATCCode_suffix= ATC_Supplemental= ATCvet= Abbreviations= Beilstein= CASNo1= CASNo1_Comment= CASNo1_Ref= CASNo2= CASNo2_Comment= CASNo2_Ref= CASNo3= CASNo3_Comment= CASNo3_Ref= CASNo4= CASNo4_Comment= CASNo4_Ref= CASNo5= CASNo5_Comment= CASNo5_Ref= CASNo= CASNoOther= CASNo_Comment= CASNo_Ref= ChEBI1= ChEBI1_Comment= ChEBI1_Ref= ChEBI2= ChEBI2_Comment= ChEBI2_Ref= ChEBI3= ChEBI3_Comment= ChEBI3_Ref= ChEBI4= ChEBI4_Comment= ChEBI4_Ref= ChEBI5= ChEBI5_Comment= ChEBI5_Ref= ChEBI= ChEBIOther= ChEBI_Comment= ChEBI_Ref= ChEMBL1= ChEMBL1_Comment= ChEMBL1_Ref= ChEMBL2= ChEMBL2_Comment= ChEMBL2_Ref= ChEMBL3= ChEMBL3_Comment= ChEMBL3_Ref= ChEMBL4= ChEMBL4_Comment= ChEMBL4_Ref= ChEMBL5= ChEMBL5_Comment= ChEMBL5_Ref= ChEMBL= ChEMBLOther= ChEMBL_Comment= ChEMBL_Ref= ChemSpiderID1= ChemSpiderID1_Comment= ChemSpiderID1_Ref= ChemSpiderID2= ChemSpiderID2_Comment= ChemSpiderID2_Ref= ChemSpiderID3= ChemSpiderID3_Comment= ChemSpiderID3_Ref= ChemSpiderID4= ChemSpiderID4_Comment= ChemSpiderID4_Ref= ChemSpiderID5= ChemSpiderID5_Comment= ChemSpiderID5_Ref= ChemSpiderID= ChemSpiderIDOther= ChemSpiderID_Comment= ChemSpiderID_Ref= DrugBank1= DrugBank1_Comment= DrugBank1_Ref= DrugBank2= DrugBank2_Comment= DrugBank2_Ref= DrugBank3= DrugBank3_Comment= DrugBank3_Ref= DrugBank4= DrugBank4_Comment= DrugBank4_Ref= DrugBank5= DrugBank5_Comment= DrugBank5_Ref= DrugBank= DrugBankOther= DrugBank_Comment= DrugBank_Ref= EC number= EC number_Comment= EC_number= EC_number_Comment= EINECS= Gmelin= IUPHAR_ligand= IUPHAR_ligand1= IUPHAR_ligand2= IUPHAR_ligand3= IUPHAR_ligand4= IUPHAR_ligand5= IUPHAR_ligand_Comment= IUPHAR_ligand1_Comment= IUPHAR_ligand2_Comment= IUPHAR_ligand3_Comment= IUPHAR_ligand4_Comment= IUPHAR_ligand5_Comment= IUPHAR_ligand_Other= InChI1= InChI1_Comment= InChI1_Ref= InChI2= InChI2_Comment= InChI2_Ref= InChI3= InChI3_Comment= InChI3_Ref= InChI4= InChI4_Comment= InChI4_Ref= InChI5= InChI5_Comment= InChI5_Ref= InChI= InChIKey1= InChIKey1_Ref= InChIKey2= InChIKey2_Ref= InChIKey3= InChIKey3_Ref= InChIKey4= InChIKey4_Ref= InChIKey5= InChIKey5_Ref= InChIKey= InChIKey_Ref= InChIOther= InChI_Comment= InChI_Ref= JmolOther= KEGG1= KEGG1_Comment= KEGG1_Ref= KEGG2= KEGG2_Comment= KEGG2_Ref= KEGG3= KEGG3_Comment= KEGG3_Ref= KEGG4= KEGG4_Comment= KEGG4_Ref= KEGG5= KEGG5_Comment= KEGG5_Ref= KEGG= KEGGOther= KEGG_Comment= KEGG_Ref= MeSHName= PubChem1= PubChem1_Comment= PubChem2= PubChem2_Comment= PubChem3= PubChem3_Comment= PubChem4= PubChem4_Comment= PubChem5= PubChem5_Comment= PubChem= PubChemOther= PubChem_Comment= RTECS= SMILES1= SMILES1_Comment= SMILES2= SMILES2_Comment= SMILES3= SMILES3_Comment= SMILES4= SMILES4_Comment= SMILES5= SMILES5_Comment= SMILESOther= SMILES= SMILES_Comment= StdInChI= StdInChIKey= StdInChIKey_Ref= StdInChI_Comment= StdInChI_Ref= UNII= UNII1= UNII1_Comment= UNII1_Ref= UNII2= UNII2_Comment= UNII2_Ref= UNII3= UNII3_Comment= UNII3_Ref= UNII4= UNII4_Comment= UNII4_Ref= UNII5= UNII5_Comment= UNII5_Ref= UNIIOther= UNII_Comment= UNII_Ref= UNNumber=

cat=Chemical articles with unknown parameter in Chembox preview=
@@@
This error is harmless. The message shows only in Preview, it will not show after Save.
|errNS=0}}
ChemSpider
{{safesubst:#invoke:collapsible list|main}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
{{#invoke:TemplatePar

|check |template=Template:Chembox |all= |opt= IUPACNames= IUPACName= ImageAlt1= ImageAlt2= ImageAlt3= ImageAlt4= ImageAltL1= ImageAltL2= ImageAltL3= ImageAltL4= ImageAltR1= ImageAltR2= ImageAltR3= ImageAltR4= ImageAlt= ImageCaption1= ImageCaption2= ImageCaption3= ImageCaption4= ImageCaptionL1= ImageCaptionL2= ImageCaptionL3= ImageCaptionL4= ImageCaptionR1= ImageCaptionR2= ImageCaptionR3= ImageCaptionR4= ImageCaption= ImageFile1_Ref= ImageFile1= ImageFile2_Ref= ImageFile2= ImageFile3_Ref= ImageFile3= ImageFile4_Ref= ImageFile4= ImageFileL1_Ref= ImageFileL1= ImageFileL2_Ref= ImageFileL2= ImageFileL3_Ref= ImageFileL3= ImageFileL4_Ref= ImageFileL4= ImageFileR1_Ref= ImageFileR1= ImageFileR2_Ref= ImageFileR2= ImageFileR3_Ref= ImageFileR3= ImageFileR4_Ref= ImageFileR4= ImageFile_Ref= ImageFile= ImageName1= ImageName2= ImageName3= ImageName4= ImageNameL1= ImageNameL2= ImageNameL3= ImageNameL4= ImageNameR1= ImageNameR2= ImageNameR3= ImageNameR4= ImageName= ImageSize1= ImageSize2= ImageSize3= ImageSize4= ImageSizeL1= ImageSizeL2= ImageSizeL3= ImageSizeL4= ImageSizeR1= ImageSizeR2= ImageSizeR3= ImageSizeR4= ImageSize= Name= OtherNames= PIN= Reference= Section1= Section2= Section3= Section4= Section5= Section6= Section7= Section8= Section9= SystematicName= Verifiedfields= Watchedfields= verifiedrevid= Verifiedimages= general_note= show_infobox_ref= show_ss_note= style-left-column-width= style= width |cat=Chemical articles with unknown parameter in Chembox

|format=0|preview=
@@@
This error is harmless. The message shows only in Preview, it will not show after Save.
|errNS=0}}

(6S)-6-Fluoroshikimic acid is an antibacterial agent acting on the aromatic biosynthetic pathway.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> It may be used against Plasmodium falciparum, the causative agent of malaria.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The molecule is targeting the enzymes of the shikimate pathway. This metabolic pathway is not present in mammals. The mechanism of action of the molecule is not through the inhibition of chorismate synthase but by the inhibition of 4-aminobenzoic acid synthesis.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

The use of the molecule led to resistances in Escherichia coli.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


(6S)-6-Fluoroshikimic acid sections
Intro   See also    References   

PREVIOUS: IntroNEXT: See also
<<>>

Journal::''s''    Category::title    Format::author    Volume::pages    Issue::pathway    Molecule::articles

(6S)-6-Fluoroshikimic acid
colspan=2 style="background:#f8eaba; text-align:center;" Names
colspan=2 style="background:#f8eaba; text-align:center;" Identifiers{{#invoke:TemplatePar check template=Template:Chembox Identifiers opt=

3DMet= ATCCode= ATCCode_prefix= ATCCode_suffix= ATC_Supplemental= ATCvet= Abbreviations= Beilstein= CASNo1= CASNo1_Comment= CASNo1_Ref= CASNo2= CASNo2_Comment= CASNo2_Ref= CASNo3= CASNo3_Comment= CASNo3_Ref= CASNo4= CASNo4_Comment= CASNo4_Ref= CASNo5= CASNo5_Comment= CASNo5_Ref= CASNo= CASNoOther= CASNo_Comment= CASNo_Ref= ChEBI1= ChEBI1_Comment= ChEBI1_Ref= ChEBI2= ChEBI2_Comment= ChEBI2_Ref= ChEBI3= ChEBI3_Comment= ChEBI3_Ref= ChEBI4= ChEBI4_Comment= ChEBI4_Ref= ChEBI5= ChEBI5_Comment= ChEBI5_Ref= ChEBI= ChEBIOther= ChEBI_Comment= ChEBI_Ref= ChEMBL1= ChEMBL1_Comment= ChEMBL1_Ref= ChEMBL2= ChEMBL2_Comment= ChEMBL2_Ref= ChEMBL3= ChEMBL3_Comment= ChEMBL3_Ref= ChEMBL4= ChEMBL4_Comment= ChEMBL4_Ref= ChEMBL5= ChEMBL5_Comment= ChEMBL5_Ref= ChEMBL= ChEMBLOther= ChEMBL_Comment= ChEMBL_Ref= ChemSpiderID1= ChemSpiderID1_Comment= ChemSpiderID1_Ref= ChemSpiderID2= ChemSpiderID2_Comment= ChemSpiderID2_Ref= ChemSpiderID3= ChemSpiderID3_Comment= ChemSpiderID3_Ref= ChemSpiderID4= ChemSpiderID4_Comment= ChemSpiderID4_Ref= ChemSpiderID5= ChemSpiderID5_Comment= ChemSpiderID5_Ref= ChemSpiderID= ChemSpiderIDOther= ChemSpiderID_Comment= ChemSpiderID_Ref= DrugBank1= DrugBank1_Comment= DrugBank1_Ref= DrugBank2= DrugBank2_Comment= DrugBank2_Ref= DrugBank3= DrugBank3_Comment= DrugBank3_Ref= DrugBank4= DrugBank4_Comment= DrugBank4_Ref= DrugBank5= DrugBank5_Comment= DrugBank5_Ref= DrugBank= DrugBankOther= DrugBank_Comment= DrugBank_Ref= EC number= EC number_Comment= EC_number= EC_number_Comment= EINECS= Gmelin= IUPHAR_ligand= IUPHAR_ligand1= IUPHAR_ligand2= IUPHAR_ligand3= IUPHAR_ligand4= IUPHAR_ligand5= IUPHAR_ligand_Comment= IUPHAR_ligand1_Comment= IUPHAR_ligand2_Comment= IUPHAR_ligand3_Comment= IUPHAR_ligand4_Comment= IUPHAR_ligand5_Comment= IUPHAR_ligand_Other= InChI1= InChI1_Comment= InChI1_Ref= InChI2= InChI2_Comment= InChI2_Ref= InChI3= InChI3_Comment= InChI3_Ref= InChI4= InChI4_Comment= InChI4_Ref= InChI5= InChI5_Comment= InChI5_Ref= InChI= InChIKey1= InChIKey1_Ref= InChIKey2= InChIKey2_Ref= InChIKey3= InChIKey3_Ref= InChIKey4= InChIKey4_Ref= InChIKey5= InChIKey5_Ref= InChIKey= InChIKey_Ref= InChIOther= InChI_Comment= InChI_Ref= JmolOther= KEGG1= KEGG1_Comment= KEGG1_Ref= KEGG2= KEGG2_Comment= KEGG2_Ref= KEGG3= KEGG3_Comment= KEGG3_Ref= KEGG4= KEGG4_Comment= KEGG4_Ref= KEGG5= KEGG5_Comment= KEGG5_Ref= KEGG= KEGGOther= KEGG_Comment= KEGG_Ref= MeSHName= PubChem1= PubChem1_Comment= PubChem2= PubChem2_Comment= PubChem3= PubChem3_Comment= PubChem4= PubChem4_Comment= PubChem5= PubChem5_Comment= PubChem= PubChemOther= PubChem_Comment= RTECS= SMILES1= SMILES1_Comment= SMILES2= SMILES2_Comment= SMILES3= SMILES3_Comment= SMILES4= SMILES4_Comment= SMILES5= SMILES5_Comment= SMILESOther= SMILES= SMILES_Comment= StdInChI= StdInChIKey= StdInChIKey_Ref= StdInChI_Comment= StdInChI_Ref= UNII= UNII1= UNII1_Comment= UNII1_Ref= UNII2= UNII2_Comment= UNII2_Ref= UNII3= UNII3_Comment= UNII3_Ref= UNII4= UNII4_Comment= UNII4_Ref= UNII5= UNII5_Comment= UNII5_Ref= UNIIOther= UNII_Comment= UNII_Ref= UNNumber=

cat=Chemical articles with unknown parameter in Chembox preview=
@@@
This error is harmless. The message shows only in Preview, it will not show after Save.
|errNS=0}}
ChemSpider
{{safesubst:#invoke:collapsible list|main}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
{{#invoke:TemplatePar

|check |template=Template:Chembox |all= |opt= IUPACNames= IUPACName= ImageAlt1= ImageAlt2= ImageAlt3= ImageAlt4= ImageAltL1= ImageAltL2= ImageAltL3= ImageAltL4= ImageAltR1= ImageAltR2= ImageAltR3= ImageAltR4= ImageAlt= ImageCaption1= ImageCaption2= ImageCaption3= ImageCaption4= ImageCaptionL1= ImageCaptionL2= ImageCaptionL3= ImageCaptionL4= ImageCaptionR1= ImageCaptionR2= ImageCaptionR3= ImageCaptionR4= ImageCaption= ImageFile1_Ref= ImageFile1= ImageFile2_Ref= ImageFile2= ImageFile3_Ref= ImageFile3= ImageFile4_Ref= ImageFile4= ImageFileL1_Ref= ImageFileL1= ImageFileL2_Ref= ImageFileL2= ImageFileL3_Ref= ImageFileL3= ImageFileL4_Ref= ImageFileL4= ImageFileR1_Ref= ImageFileR1= ImageFileR2_Ref= ImageFileR2= ImageFileR3_Ref= ImageFileR3= ImageFileR4_Ref= ImageFileR4= ImageFile_Ref= ImageFile= ImageName1= ImageName2= ImageName3= ImageName4= ImageNameL1= ImageNameL2= ImageNameL3= ImageNameL4= ImageNameR1= ImageNameR2= ImageNameR3= ImageNameR4= ImageName= ImageSize1= ImageSize2= ImageSize3= ImageSize4= ImageSizeL1= ImageSizeL2= ImageSizeL3= ImageSizeL4= ImageSizeR1= ImageSizeR2= ImageSizeR3= ImageSizeR4= ImageSize= Name= OtherNames= PIN= Reference= Section1= Section2= Section3= Section4= Section5= Section6= Section7= Section8= Section9= SystematicName= Verifiedfields= Watchedfields= verifiedrevid= Verifiedimages= general_note= show_infobox_ref= show_ss_note= style-left-column-width= style= width |cat=Chemical articles with unknown parameter in Chembox

|format=0|preview=
@@@
This error is harmless. The message shows only in Preview, it will not show after Save.
|errNS=0}}

(6S)-6-Fluoroshikimic acid is an antibacterial agent acting on the aromatic biosynthetic pathway.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> It may be used against Plasmodium falciparum, the causative agent of malaria.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The molecule is targeting the enzymes of the shikimate pathway. This metabolic pathway is not present in mammals. The mechanism of action of the molecule is not through the inhibition of chorismate synthase but by the inhibition of 4-aminobenzoic acid synthesis.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

The use of the molecule led to resistances in Escherichia coli.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


(6S)-6-Fluoroshikimic acid sections
Intro   See also    References   

PREVIOUS: IntroNEXT: See also
<<>>