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Troparil (also known as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT) is a stimulant drug used in scientific research. Troparil is a phenyltropane based dopamine reuptake inhibitor (DRI) and is derived from methylecgonidine. Troparil is documented to be a few times more potent than cocaine as a dopamine reuptake inhibitor,<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> but is less potent as a serotonin reuptake inhibitor,<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> and has a duration spanning a few times longer, since the phenyl ring is directly connected to tropane through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.


Troparil sections
Intro  Background  Application    Legality   See also   References   

PREVIOUS: IntroNEXT: Background
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Troparil (also known as (–)-2β-Carbomethoxy-3β-phenyltropane, WIN 35,065-2, or β-CPT) is a stimulant drug used in scientific research. Troparil is a phenyltropane based dopamine reuptake inhibitor (DRI) and is derived from methylecgonidine. Troparil is documented to be a few times more potent than cocaine as a dopamine reuptake inhibitor,<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> but is less potent as a serotonin reuptake inhibitor,<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> and has a duration spanning a few times longer, since the phenyl ring is directly connected to tropane through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.


Troparil sections
Intro  Background  Application    Legality   See also   References   

PREVIOUS: IntroNEXT: Background
<<>>