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Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and regulates intimately the SNARE zipping

SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells.<ref name="gerald2002"> {{#invoke:Citation/CS1|citation |CitationClass=journal }} </ref> The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.


SNARE (protein) sections
Intro   Types    Structure    Membrane fusion    Components    Mechanism of membrane fusion   Regulatory Effects on Exocytosis   Toxins    Role in neurotransmitter release    Role in autophagy   References  External links  

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Journal::snare    Membrane::fusion    Title::volume    Pages::proteins    Complex::snap-    Issue::vauthors

Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and regulates intimately the SNARE zipping

SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells.<ref name="gerald2002"> {{#invoke:Citation/CS1|citation |CitationClass=journal }} </ref> The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.


SNARE (protein) sections
Intro   Types    Structure    Membrane fusion    Components    Mechanism of membrane fusion   Regulatory Effects on Exocytosis   Toxins    Role in neurotransmitter release    Role in autophagy   References  External links  

PREVIOUS: IntroNEXT: Types
<<>>