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The one gene-one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an influential 1941 paper<ref name="PNAS 1941"> {{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> on genetic mutations in the mold Neurospora crassa, and subsequently was dubbed the "one gene-one enzyme hypothesis" by their collaborator Norman Horowitz.<ref name="Fruton, p. 434">Fruton, p. 434</ref> In 2004 Norman Horowitz reminisced that “these experiments founded the science of what Beadle and Tatum called ‘biochemical genetics.’ In actuality they proved to be the opening gun in what became molecular genetics and all the developments that have followed from that.”<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The development of the one gene-one enzyme hypothesis is often considered the first significant result in what came to be called molecular biology.<ref>Morange, p. 21</ref> Although it has been extremely influential, the hypothesis was recognized soon after its proposal to be an oversimplification. Even the subsequent reformulation of the "one gene-one polypeptide" hypothesis is now considered too simple to describe the relationship between genes and proteins.<ref> {{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


One gene-one enzyme hypothesis sections
Intro  Origin  The hypothesis and alternative interpretations  Possible anticipation of Beadle and Tatum's results  See also  References  Further reading  

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The one gene-one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an influential 1941 paper<ref name="PNAS 1941"> {{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> on genetic mutations in the mold Neurospora crassa, and subsequently was dubbed the "one gene-one enzyme hypothesis" by their collaborator Norman Horowitz.<ref name="Fruton, p. 434">Fruton, p. 434</ref> In 2004 Norman Horowitz reminisced that “these experiments founded the science of what Beadle and Tatum called ‘biochemical genetics.’ In actuality they proved to be the opening gun in what became molecular genetics and all the developments that have followed from that.”<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> The development of the one gene-one enzyme hypothesis is often considered the first significant result in what came to be called molecular biology.<ref>Morange, p. 21</ref> Although it has been extremely influential, the hypothesis was recognized soon after its proposal to be an oversimplification. Even the subsequent reformulation of the "one gene-one polypeptide" hypothesis is now considered too simple to describe the relationship between genes and proteins.<ref> {{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>


One gene-one enzyme hypothesis sections
Intro  Origin  The hypothesis and alternative interpretations  Possible anticipation of Beadle and Tatum's results  See also  References  Further reading  

PREVIOUS: IntroNEXT: Origin
<<>>