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Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes.<ref name=Peb2010>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> This is done in an attempt to reduce the risk of tissue injury from lack of blood flow.<ref name=Bernard2002>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Periods of poor blood flow may be due to cardiac arrest or the blockage of an artery by a clot as in the case of a stroke.

Targeted temperature management improves survival and brain function following resuscitation from cardiac arrest.<ref name=Arrich2012>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Evidence supports its use following certain types of cardiac arrest in which an individual does not regain consciousness.<ref name=Peb2010/> Both {{safesubst:#invoke:convert|convert}} and {{safesubst:#invoke:convert|convert}} appear to result in similar outcomes.<ref name=ILCOR2013>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Niel2013"/> Targeted temperature management following traumatic brain injury has shown mixed results with some studies showing benefits in survival and brain function while other show no clear benefit.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> While associated with some complications, these are generally mild.<ref name=Xiao2013>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

Targeted temperature management is thought to prevent brain injury by several methods including decreasing the brain's oxygen demand, reducing the production of neurotransmitters like glutamate, as well as reducing free radicals that might damage the brain. The lowering of body temperature may be accomplished by many means including the use of cooling blankets, cooling helmets, cooling catheters, ice packs and ice water lavage.


Targeted temperature management sections
Intro  Medical uses  Adverse effects  Mechanism  Methods  History  References  External links  

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First::journal    Title::cooling    Pages::volume    Issue::arrest    Convert::cardiac    Brain::after

{{#invoke:Hatnote|hatnote}} {{#invoke:Infobox|infobox}}

Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes.<ref name=Peb2010>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> This is done in an attempt to reduce the risk of tissue injury from lack of blood flow.<ref name=Bernard2002>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Periods of poor blood flow may be due to cardiac arrest or the blockage of an artery by a clot as in the case of a stroke.

Targeted temperature management improves survival and brain function following resuscitation from cardiac arrest.<ref name=Arrich2012>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> Evidence supports its use following certain types of cardiac arrest in which an individual does not regain consciousness.<ref name=Peb2010/> Both {{safesubst:#invoke:convert|convert}} and {{safesubst:#invoke:convert|convert}} appear to result in similar outcomes.<ref name=ILCOR2013>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Niel2013"/> Targeted temperature management following traumatic brain injury has shown mixed results with some studies showing benefits in survival and brain function while other show no clear benefit.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref> While associated with some complications, these are generally mild.<ref name=Xiao2013>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

Targeted temperature management is thought to prevent brain injury by several methods including decreasing the brain's oxygen demand, reducing the production of neurotransmitters like glutamate, as well as reducing free radicals that might damage the brain. The lowering of body temperature may be accomplished by many means including the use of cooling blankets, cooling helmets, cooling catheters, ice packs and ice water lavage.


Targeted temperature management sections
Intro  Medical uses  Adverse effects  Mechanism  Methods  History  References  External links  

PREVIOUS: IntroNEXT: Medical uses
<<>>