::SNARE (protein)
::concepts
Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and regulates intimately the SNARE zipping
SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells.<ref name="gerald2002"> {{#invoke:Citation/CS1|citation |CitationClass=journal }} </ref> The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.
SNARE (protein) sections
Intro Types Structure Membrane fusion Components Mechanism of membrane fusion Regulatory Effects on Exocytosis Toxins Role in neurotransmitter release Role in autophagy References External links
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SNARE proteins (an acronym derived from "SNAP (Soluble NSF Attachment Protein) REceptor") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells.<ref name="gerald2002"> {{#invoke:Citation/CS1|citation |CitationClass=journal }} </ref> The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.
SNARE (protein) sections
Intro Types Structure Membrane fusion Components Mechanism of membrane fusion Regulatory Effects on Exocytosis Toxins Role in neurotransmitter release Role in autophagy References External links
| PREVIOUS: Intro | NEXT: Types |
| << | >> |